The discovery of thousands of extrasolar planets is revolutionizing our views of the universe. It seems clear that planets are common around stars and, with about 100 billion stars in our galaxy, organic life cannot be that rare. Of course, "organic life" doesn't mean "intelligent life," and the latter doesn't mean "technologically advanced civilization." But, with so many planets, the galaxy may well be teeming with alien civilizations, some of them technologically as advanced as us, possibly much more.
The next step in this line of reasoning is called the "Fermi Paradox," said to have been proposed for the first time by the physicist Enrico Fermi in the 1950s: "if aliens exist, why aren't they here?" Even at speeds slower than light, nothing physical prevents a spaceship from crossing the galaxy from end to end in a million years or even less. Since our galaxy is more than 10 billion years old, intelligent aliens would have had plenty of time to explore and colonize every star in the galaxy. But we don't see aliens around, and that's the paradox.
One possible interpretation of the paradox is that we are alone as sentient beings in the galaxy, perhaps in the whole universe. There may be a bottleneck, also known as the "Great Filter," that stops organic life from developing into the kind of civilization that engages in space-faring.
Paradoxes are often extremely useful scientific tools. They state that two contrasting beliefs cannot be both true, and that's usually powerful evidence that some of our assumptions are not correct. The Fermi paradox is not so much about whether alien civilizations are common or not, but about the idea that interstellar travel is possible. It may simply be telling us that traveling from one star to another is very difficult, perhaps impossible. It is not enough to say that a future civilization will know things we can't even imagine. Any technology must obey the laws of physics. And that puts limits to what it can achieve.
The problem of interstellar travel is not so much about how to build an interstellar spaceship. Already in the 1950s, some designs had been proposed that could do the job. An "Orion" starship would move by riding nuclear explosions at its back, and it was calculated that it could reach the nearest stars in a century or so. Of course, it would be a daunting task to build one, but there is no reason to think that it would be impossible. More advanced versions might use more exotic energy sources: antimatter or even black holes.
The real problem is not technology, it is cost. Building a fleet of interstellar spaceships requires a huge expenditure of resources that should be maintained for a time sufficiently long to carry out an interstellar exploration program - thousands of years at least. An estimate of the minimum power that a civilization needs to engage in sustained interstellar travel is of the order of 1000 terawatts (TW). It is just a guess, but it has some logic. The power installed today on our planet is approximately 18 TW and the most we could do with that was to explore the planets of our system, and even that rather sporadically. Clearly, to explore the stars, we need much more.
Of course, we are not getting close, and we may well soon start moving in the opposite direction. John Greer and Tim O'Reilly may have been the first to note that the "great filter" that generates the Fermi paradox could be explained in terms of the limitations of fossil fuels on Earth-like planets. Because of the "bell-shaped" production curve of a limited resource, a civilization flares up and then collapses. I dubbed this phenomenon the "Hubbert Hurdle" in 2011. The hurdle may be especially difficult to overcome if the Seneca effect kicks in, making the decline even faster, a true collapse.
Let's start with the technology we know: nuclear fission. Fissile elements (more exactly, "nuclides") are those that can create the kind of chain reaction that can be harnessed as an energy source. Only one of these nuclides occurs naturally in substantial amounts in the universe: the 235 isotope of uranium. It is a curious quirk of the laws of physics that this nuclide exists, alone. It is created in the explosions of supernova stars and also in the merging of neutron stars. It has accumulated on Earth's surface in amounts sufficient for humans to exploit to build tens of thousands of nuclear warheads and to currently produce about 0.3 TW of power. Fission could power a simple version of the Orion spaceship, but could it power a civilization able to explore the galaxy? Probably not.
There is one more possibility: nuclear fusion, the poster child of the Atomic Age. The idea that was common in the 1950s is that nuclear fusion was the obvious next step after fission. We would have had energy "too cheap to meter." And not only that: fusion can use hydrogen isotopes, and hydrogen is the most abundant element in the universe. A hydrogen-powered starship could refuel almost anywhere in the galaxy. Hopping from one star to another, a fusion-based galactic empire would be perfectly possible.
All this is very speculative, but we arrived at a concept entirely different from the one that is at the basis of the Fermi paradox: the idea, typical of the 1950s, that a civilization keeps always expanding and that it rapidly arrives to master energy flows several orders of magnitude larger than what we can do now (sometimes called the "Kardashev Scale.").